When men search for an effective solution to erectile dysfunction (ED), the first question is often “which pill works best for me?” Levitra Professional (the brand name for vardenafil) sits alongside a handful of well‑known rivals, but the nuances matter. This guide breaks down how Levitra stacks up against its major alternatives, looks at real‑world factors like cost and side‑effects, and helps you decide which option fits your lifestyle.
What is Levitra Professional (Vardenafil)?
Levitra Professional (also marketed as Vardenafil) is a prescription medication classified as a phosphodiesterase‑type 5 (PDE5) inhibitor. It works by relaxing the smooth muscle in the penile arteries, allowing increased blood flow when sexual stimulation occurs.
Key attributes of Levitra Professional:
- Typical dose: 10 mg taken about 25‑60 minutes before intercourse.
- Onset of action: 30 minutes for most men.
- Effective window: Up to 5 hours, giving a flexible timeline.
- Metabolism: Primarily via CYP3A4 enzymes, so certain antifungals or antibiotics can raise levels.
- Common side‑effects: Headache, flushing, nasal congestion, and mild visual changes.
Major Alternatives on the Market
While Levitra Professional is popular, three other PDE5 inhibitors dominate the shelf‑talk:
- Viagra (generic name Sildenafil) - the first‑ever oral ED drug, approved in 1998.
- Cialis (generic name Tadalafil) - notable for its long‑lasting effect, up to 36 hours.
- Stendra (generic name Avanafil) - the newest entrant, praised for rapid onset.
All four belong to the broader PDE5 inhibitor class, meaning they share a core mechanism but differ in pharmacokinetics, dosage flexibility, and tolerability.
Head‑to‑Head Comparison Table
| Attribute | Levitra Professional (Vardenafil) | Viagra (Sildenafil) | Cialis (Tadalafil) | Stendra (Avanafil) |
|---|---|---|---|---|
| Typical Dose | 10 mg (adjustable to 5 mg or 20 mg) | 50 mg (adjustable to 25 mg or 100 mg) | 10 mg (adjustable to 5 mg or 20 mg) | 100 mg (adjustable to 50 mg) |
| Onset | 30 min (some report 15 min) | 30‑60 min | 30‑120 min | 15 min (fastest among the group) |
| Duration | 4‑5 hours | 4‑5 hours | Up to 36 hours | 6‑12 hours |
| Food Interaction | High‑fat meals may delay onset slightly | Heavy meals, especially fatty, can reduce effectiveness | Minimal impact | Little to none |
| Common Side‑effects | Headache, flushing, nasal congestion | Headache, dyspepsia, visual tint | Back pain, muscle aches, indigestion | Headache, dizziness, nasal congestion |
| Cost (UK, 2025) | £1.20 per tablet (generic) | £1.00 per tablet (generic) | £1.40 per tablet (generic) | £1.60 per tablet (generic) |
| Prescription Status (UK) | Prescription‑only medicine (POM) | POM | POM | POM |
The table highlights that each drug shines in a different area. If you value a quick “in‑and‑out” experience, Stendra’s 15‑minute onset may win you over. For weekend spontaneity, Cialis’ 36‑hour window is unrivaled. Levitra offers a solid middle ground with a slightly faster onset than Viagra and a narrower therapeutic window than Cialis.
Choosing the Right Pill for Your Situation
Below is a quick decision‑tree you can run through mentally:
- If you need the fastest kick‑in, Stendra is the clear pick.
- If you prefer a drug that stays effective for an entire day or weekend, go with Cialis.
- If you’re looking for a balance between speed and duration, Levitra Professional fits well.
- If cost is the primary driver and you don’t mind a slightly slower onset after a heavy meal, Viagra (generic sildenafil) remains a solid, budget‑friendly choice.
Remember, personal health factors matter. Men with cardiovascular disease, liver impairment, or those taking nitrates should avoid any PDE5 inhibitor. Always discuss medication history with a GP or sexual health specialist.
Cost, Availability, and Insurance Considerations in the UK
All four drugs are classified as prescription‑only medicines (POM) in the United Kingdom. This means you’ll need a valid prescription from a qualified clinician.
Typical retail prices in 2025 (based on 30‑day supply):
- Generic Levitra (vardenafil) - £1.20 per tablet.
- Generic Viagra (sildenafil) - £1.00 per tablet.
- Generic Cialis (tadalafil) - £1.40 per tablet.
- Generic Stendra (avanafil) - £1.60 per tablet.
Many NHS prescriptions now come with a standard prescription charge (£9.35 in England as of 2025). Certain patient groups (e.g., under‑65 with low income) may qualify for free prescriptions, which can make any of these options financially viable.
Practical Tips and Common Pitfalls
- Timing matters: Take the pill on an empty stomach for faster absorption. High‑fat meals can delay effects, especially with Viagra and Levitra.
- Don’t double up: If the effect isn’t felt after the expected window, wait at least 24 hours before retaking. Over‑dosing raises the risk of severe headaches and low blood pressure.
- Alcohol moderation: Light drinks are fine, but large quantities can blunt the erection and amplify side‑effects.
- Medication interactions: Nitrates (e.g., nitroglycerin) are an absolute contraindication. Certain antifungals (ketoconazole) and antibiotics (clarithromycin) can raise PDE5 levels, requiring dose adjustments.
- Medical check‑up: A baseline blood pressure reading and discussion of cardiovascular health are essential before starting any PDE5 inhibitor.
Mini‑FAQ - Answers to the Most Pressing Questions
How long does Levitra Professional stay in my system?
Vardenafil has an elimination half‑life of about 4‑5 hours, so most of the drug clears within a day. Residual traces can be detected in urine for up to 24 hours.
Can I take Levitra with a daily low‑dose aspirin?
Yes, low‑dose aspirin (75‑81 mg) does not interact with vardenafil. However, avoid combining PDE5 inhibitors with blood thinners like warfarin without doctor supervision.
Is it safe to use Levitra if I have diabetes?
Diabetes itself isn’t a contraindication, but the condition can affect blood vessel health. Many men with well‑controlled diabetes use Levitra successfully, though they should start at a lower dose and monitor blood pressure.
What should I do if I experience a painful erection lasting more than 4 hours?
Seek emergency medical care immediately. A prolonged erection (priapism) can cause permanent tissue damage. Prompt treatment, usually with an injection or oral medication, is critical.
Which PDE5 inhibitor works best for smokers?
Smoking narrows blood vessels, reducing the effectiveness of all PDE5 inhibitors. Some studies suggest avanafil (Stendra) maintains efficacy better in smokers due to its rapid onset, but quitting smoking remains the top recommendation.
Choosing the right ED medication isn’t a one‑size‑fits‑all decision. By understanding how Levitra Professional compares with Viagra, Cialis, and Stendra, you can align the drug’s performance profile with your lifestyle, health status, and budget. Always involve a qualified healthcare professional before starting any treatment, and you’ll be on the right track toward a satisfying sexual life.
